Antibiotic Resistance Mediated by the MacB ABC Transporter Family: A Structural and Functional Perspective
The MacB ABC transporter forms a tripartite efflux pump with the MacA adaptor protein and TolC outer membrane exit duct to expel antibiotics and export virulence factors from Gram-negative bacteria.Here, we review recent structural party yard cup and functional data on MacB and its homologs.MacB has a fold that is distinct from other structurally c